Watch DFW, once our brightest light, doomed by the lack of knowledge of the effects of bad chemicals on our brains.
Here's David Foster Wallace, on the Charlie Rose show: http://www.youtube.com/watch?v=qm3yuWEvCgw
And here's his good friend, Jonathan Franzen, on Author Video:
Anyone who is writing nowadays needs to be familiar with these gentlemen and their work, and remember the importance of simple things, like spelling, syntax, and the the mind of the reader. Read, then write, then read some more.